• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

Etifoxine hydrochloride

CAS No. 56776-32-0

Etifoxine hydrochloride ( HOE 36-801 hydrochloride )

产品货号. M22932 CAS No. 56776-32-0

依替福辛是一种抗焦虑和抗惊厥化合物。与苯二氮卓类化合物不同,依托替福辛似乎通过与 GABAA 受体复合物的 β2 和 β3 亚基结合来产生抗焦虑作用,因此作用于与苯二氮卓类化合物不同的靶位点,尽管产生的生理作用与苯二氮卓类化合物相似。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥275 有现货
5MG ¥446 有现货
10MG ¥648 有现货
25MG ¥1239 有现货
50MG ¥2252 有现货
100MG ¥3993 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Etifoxine hydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    依替福辛是一种抗焦虑和抗惊厥化合物。与苯二氮卓类化合物不同,依托替福辛似乎通过与 GABAA 受体复合物的 β2 和 β3 亚基结合来产生抗焦虑作用,因此作用于与苯二氮卓类化合物不同的靶位点,尽管产生的生理作用与苯二氮卓类化合物相似。
  • 产品描述
    Etifoxine is an anxiolytic and anticonvulsant drug.?Unlike benzodiazepines, etifoxine appears to produce its anxiolytic effects by binding to β2 and β3 subunits of the GABAA receptor complex, and so is acting at a different target site to benzodiazepines, although the physiological effect that is produced is similar to that of benzodiazepines.(In Vitro):Etifoxine (EFX), at concentrations ranging from 10 to 300 μM (higher concentrations limited its solubility), produces a dose-dependent increase in the [3H]muscimol binding at equilibrium, to 155±2% of its control value at 300 μM EFX.(In Vivo):Etifoxine competitively inhibits [35S]TBPS binding with micromolar potency in rat brain.Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice.
  • 体外实验
    Etifoxine (EFX), at concentrations ranging from 10 to 300 μM (higher concentrations limited its solubility), produces a dose-dependent increase in the [3H]muscimol binding at equilibrium, to 155±2% of its control value at 300 μM EFX.
  • 体内实验
    Etifoxine competitively inhibits [35S]TBPS binding with micromolar potency in rat brain.Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice. Animal Model:Six-week old BALB/cByJ and C57BL/6J mice (20-25 g).Dosage:3.125-50 mg/kg.Administration:Intraperitoneal inhection.Result:Significantly increased the amount of time spent on the open arms at the 12.5 mg/kg dose when compared to vehicle (p = 0.009) in BALB/cByJ mice but produced no effect in C57B/6J mice.BALB/cByJ mice compared with C57BL/6J mice exhibited significantly (p < 0.012) lower plasma levels of the compound at 15 and 30 min.
  • 同义词
    HOE 36-801 hydrochloride
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    GABA
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    56776-32-0
  • 分子量
    337.24
  • 分子式
    C17H18Cl2N2O
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:50 mg/mL (148.26 mM; Need ultrasonic)
  • SMILES
    ClC1=CC=C2C(C(C3=CC=CC=C3)(C)OC(NCC)=N2)=C1.Cl
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Verleye M, Dumas S, Heulard I, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol. 2011 Jun;21(6):457-70.
产品手册
关联产品
  • Fenchlonine

    4-氯-DL-苯丙氨酸是一种医药中间体。

  • FB23

    FB23 直接与 FTO 结合并选择性抑制 FTO 的 m6A 去甲基酶活性。 (FTO 是一种 mRNA N6-甲基腺苷 (m6A) 去甲基酶,据报道可促进白血病发生。)

  • α-Cyclopentyl-4-(2-q...

    通过计算机辅助方法,α-环戊基-4-(2-喹啉基甲氧基)苯乙酸被鉴定为 hLTA4H 和 hLTC4S 酶的可能双重抑制剂。